Prescription Drugs

Ban of Controversial Painkiller Dramatically Cuts Suicides in UK

admin — Tue, 09 Mar 2010 11:00:28 +0000

(NaturalNews) The withdrawal of a popular painkiller from the market in the United Kingdom has led to a dramatic decrease in the number of suicides and accidental overdoses in that country, according to a study conducted by researchers from Oxford University’s Centre for Suicide Research and published in the British Medical Journal.The drug in question is a combination of the narcotic painkiller dextropropoxyphene (in the opioid family) with the over-the-counter painkiller acetaminophen, also known as paracetamol or Tylenol. In the United Kingdom, the drug was marketed as co-proxamol, but it is also known as Darvon with APAP, Capadex, Di-Antalvic, Di-Gesic and Lentogesic.In 2005, the British Medicines and Healthcare Products Regulatory Agency (MHRA) decided to remove co-proxamol from the m…

Ban of Controversial Painkiller Dramatically Cuts Suicides in UK is a post from: Prescription Drugs

Long-term antidyskinetic efficacy of amantadine in Parkinson’s disease

admin — Mon, 08 Mar 2010 10:41:04 +0000

Several randomized placebo-controlled trials have consistently shown antidyskinetic effects of amantadine in levodopa treated patients with advanced Parkinson’s disease (PD). However, all of these were of short duration and there have been claims that the effect of amantadine on levodopa induced dyskinesias (LID’s) wear off after about 9 months of treatment. This randomized placebo-controlled parallel-group study was performed to assess the long-term antidyskinetic effect of amantadine in 32 PD patients, who after having been on stable amantadine therapy for LID over at least one year- were switched in a double blind manner to amantadine or placebo and followed for 3 weeks. Dyskinesia duration and intensity were assessed by UPDRS IV items 32 and 33 as well as by patient’s diaries. The prim…

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Long-term antidyskinetic efficacy of amantadine in Parkinson’s disease is a post from: Prescription Drugs

Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs.

admin — Mon, 08 Mar 2010 10:41:03 +0000

Authors: Dapat C, Suzuki Y, Saito R, Kyaw Y, Myint YY, Lin N, Oo HN, Oo KY, Win N, Naito M, Hasegawa G, Dapat IC, Zaraket H, Baranovich T, Nishikawa M, Saito T, Suzuki H
In 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2.
PMID: 20202427 [PubMed - as supplied by publisher] (Source: Emerging Infectious Diseases)

Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs. is a post from: Prescription Drugs

Is the drug-induced hypersensitivity syndrome (DIHS) due to human herpesvirus 6 infection or to allergy-mediated viral reactivation? Report of a case and literature review

admin — Sun, 07 Mar 2010 22:40:41 +0000

Conclusions: The search for rare causes of fever led to complete resolution of a very difficult case. As DIHS is a rare disease the most relevant issue is to suspect and include it in differential diagnosis of fevers of unknown origin. Once diagnosed, the therapy is easy (steroidal administration) and often successful. However our case strongly confirms that attention should be paid on the steroidal tapering that should be very slow to avoid a relapse. (Source: BMC Infectious Diseases) Is the drug-induced hypersensitivity syndrome (DIHS) due to human herpesvirus 6 infection or ...

Is the drug-induced hypersensitivity syndrome (DIHS) due to human herpesvirus 6 infection or to allergy-mediated viral reactivation? Report of a case and literature review is a post from: Prescription Drugs

Painkillers may increase risk of hearing loss

admin — Sun, 07 Mar 2010 22:40:30 +0000

In a study, men who regularly use analgesics reported hearing loss. Perhaps it wasn’t those years of listening to rock ‘n’ roll that damaged my hearing after all; regular use of aspirin, acetaminophen and other analgesics appears to substantially increase the risk of hearing loss, especially in men younger than 50. (Source: L.A. Times – Health) Painkillers may increase risk of hearing loss is a post from: Prescription Drugs

Painkillers may increase risk of hearing loss is a post from: Prescription Drugs

Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53.

admin — Sun, 07 Mar 2010 17:40:12 +0000

Authors: Carney BK, Cassimeris L
Stathmin, a microtubule regulatory protein, is overexpressed in many cancers and required for survival of several cancer lines. In a study of breast cancer cell lines, Alli et al. (Oncogene. 26:1003-12) proposed that stathmin is required for survival of cells lacking p53, but this hypothesis was not tested directly. Here we tested their hypothesis by examining cell survival in cells depleted of stathmin, p53 or both proteins. Comparing HCT116 colon cancer cell lines differing in TP53 genotype, stathmin depletion resulted in significant death only in cells lacking p53. As a second experimental system, we compared the effects of stathmin depletion from HeLa cells, which normally lack detectable levels of p53 due to expression of the HPV E6 protein. Stathm…

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Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53. is a post from: Prescription Drugs

NIRAVAM (Alprazolam) Tablet, Orally Disintegrating [Azur Pharma Inc.]

admin — Sat, 06 Mar 2010 18:00:12 +0000

Updated Date: Mar 5, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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NIRAVAM (Alprazolam) Tablet, Orally Disintegrating [Azur Pharma Inc.] is a post from: Prescription Drugs

NAPROSYN (Naproxen) Tablet EC-NAPROSYN (Naproxen) Tablet, Delayed Release NAPROSYN (Naproxen) Suspension ANAPROX (Naproxen Sodium) Tablet ANAPROX DS (Naproxen Sodium) Tablet [Hoffmann-La Roche Inc]

admin — Sat, 06 Mar 2010 18:00:10 +0000

Updated Date: Mar 5, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)) MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources. NAPROSYN (Naproxen) Tablet EC-NAPROSYN (Naproxen) Tablet, Delayed Release NAPROSYN (Naproxen) Suspension ANAPROX (Naproxen Sodium) Tablet ANAPROX DS (Naproxen Sodium) Tablet [Hoffmann-La Roche Inc] is a post from: Prescription Drugs

NAPROSYN (Naproxen) Tablet EC-NAPROSYN (Naproxen) Tablet, Delayed Release NAPROSYN (Naproxen) Suspension ANAPROX (Naproxen Sodium) Tablet ANAPROX DS (Naproxen Sodium) Tablet [Hoffmann-La Roche Inc] is a post from: Prescription Drugs

Meta-Analysis of the Efficacy and Safety of Naproxen Sodium in the Acute Treatment of Migraine

admin — Sat, 06 Mar 2010 18:00:10 +0000

Conclusions.[mdash] The available evidence suggests that naproxen sodium is more effective but may cause more adverse events than placebo in the acute treatment of moderate to severe migraine. It is effective in reducing headache intensity, rendering pain-free at 2 hours and improving migraine-associated symptoms. However, its effectiveness relative to other active comparators needs to be better defined by appropriate head-to-head clinical trials. (Headache 2010;[bull][bull]:[bull][bull]-[bull][bull]) (Source: Headache: The Journal of Head and Face Pain) Meta-Analysis of the Efficacy and Safety of Naproxen Sodium in the Acute Treatment of Migraine is a post ...

Meta-Analysis of the Efficacy and Safety of Naproxen Sodium in the Acute Treatment of Migraine is a post from: Prescription Drugs

Silencing Glycogen Synthase Kinase-3{beta} Inhibits Acetaminophen Hepatotoxicity and Attenuates JNK Activation and Loss of Glutamate Cysteine Ligase and Myeloid Cell Leukemia Sequence 1 [Signal Transduction]

admin — Sat, 06 Mar 2010 10:20:27 +0000

Previously we demonstrated that c-Jun N-terminal kinase (JNK) plays a central role in acetaminophen (APAP)-induced liver injury. In the current work, we examined other possible signaling pathways that may also contribute to APAP hepatotoxicity. APAP treatment to mice caused glycogen synthase kinase-3β (GSK-3β) activation and translocation to mitochondria during the initial phase of APAP-induced liver injury (~1 h). The silencing of GSK-3β, but not Akt-2 (protein kinase B) or glycogen synthase kinase-3 (GSK-3), using antisense significantly protected mice from APAP-induced liver injury. The silencing of GSK-3β affected several key pathways important in conferring protection against APAP-induced liver injury. APAP treatment was observed to promote the loss of glutamate cy…

Silencing Glycogen Synthase Kinase-3{beta} Inhibits Acetaminophen Hepatotoxicity and Attenuates JNK Activation and Loss of Glutamate Cysteine Ligase and Myeloid Cell Leukemia Sequence 1 [Signal Transduction] is a post from: Prescription Drugs