Prescription Drugs » Baclofen http://www.prescriptiondrugs2go.com Popoular Prescription Drugs Latest News Fri, 10 Sep 2010 08:00:04 +0000 http://wordpress.org/?v=2.8.5 en hourly 1 Review: Procedure- and Device-Related Complications of Intrathecal Baclofen Administration for Management of Adult Muscle Hypertonia: A Review http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/review-procedure-and-device-related-complications-of-intrathecal-baclofen-administration-for-management-of-adult-muscle-hypertonia-a-review.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/review-procedure-and-device-related-complications-of-intrathecal-baclofen-administration-for-management-of-adult-muscle-hypertonia-a-review.html#comments Fri, 03 Sep 2010 03:01:14 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/review-procedure-and-device-related-complications-of-intrathecal-baclofen-administration-for-management-of-adult-muscle-hypertonia-a-review.html Review: Procedure- and Device-Related Complications of Intrathecal Baclofen Administration for Management of Adult Muscle Hypertonia: A Review is a post from: Prescription Drugs

]]> Conclusions. Catheter problems are relatively common and more frequent than pump or surgical procedure complications after ITB pump implantation. Higher complication rates should be expected in centers that follow patients for a longer period of time. Standardized data collection and complication-reporting procedures along with appropriate training should be implemented in centers offering ITB treatment for management of muscle hypertonia. (Source: Neurorehabilitation and Neural Repair)

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Review: Procedure- and Device-Related Complications of Intrathecal Baclofen Administration for Management of Adult Muscle Hypertonia: A Review is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/review-procedure-and-device-related-complications-of-intrathecal-baclofen-administration-for-management-of-adult-muscle-hypertonia-a-review.html/feed 0 Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut {micro}1-receptor coupled to 5-HT1A, D2, and GABAB systems http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/orally-administered-soymorphins-soy-derived-opioid-peptides-suppress-feeding-and-intestinal-transit-via-gut-micro1-receptor-coupled-to-5-ht1a-d2-and-gabab-systems-2.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/orally-administered-soymorphins-soy-derived-opioid-peptides-suppress-feeding-and-intestinal-transit-via-gut-micro1-receptor-coupled-to-5-ht1a-d2-and-gabab-systems-2.html#comments Thu, 02 Sep 2010 02:42:20 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/orally-administered-soymorphins-soy-derived-opioid-peptides-suppress-feeding-and-intestinal-transit-via-gut-micro1-receptor-coupled-to-5-ht1a-d2-and-gabab-systems-2.html Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut {micro}1-receptor coupled to 5-HT1A, D2, and GABAB systems is a post from: Prescription Drugs

]]> We previously reported that soymorphins, µ-opioid agonist peptides derived from soy β-conglycinin β-subunit, have anxiolytic-like activity. The aim of this study was to investigate the effects of soymorphins on food intake and gut motility, along with their mechanism. We found that soymorphins decreases food intake after oral administration in fasted mice. Orally administered soymorphins suppressed small intestinal transit at lower dose than that of anorexigenic activity. Suppression of food intake and small intestinal transit after oral administration of soymorphins was inhibited by naloxone or naloxonazine, antagonists of µ- or µ1-opioid receptor, respectively, after oral but not intraperitoneal administration. The inhibitory activities of small intestinal tra…

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Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut {micro}1-receptor coupled to 5-HT1A, D2, and GABAB systems is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/orally-administered-soymorphins-soy-derived-opioid-peptides-suppress-feeding-and-intestinal-transit-via-gut-micro1-receptor-coupled-to-5-ht1a-d2-and-gabab-systems-2.html/feed 0 Acute Intrathecal Baclofen Withdrawal: A Brief Review of Treatment Options http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/acute-intrathecal-baclofen-withdrawal-a-brief-review-of-treatment-options.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/acute-intrathecal-baclofen-withdrawal-a-brief-review-of-treatment-options.html#comments Thu, 26 Aug 2010 04:22:16 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/acute-intrathecal-baclofen-withdrawal-a-brief-review-of-treatment-options.html Acute Intrathecal Baclofen Withdrawal: A Brief Review of Treatment Options is a post from: Prescription Drugs

]]> Conclusions  Critical care practitioners should be prepared to treat this potentially devastating and often refractory complication of
ITB therapy.

Content Type Journal ArticleDOI 10.1007/s12028-010-9422-6Authors
James C. Ross, Department of Pharmacy, Saint Joseph Health System, 1 Saint Joseph Dr, Lexington, KY 40504, USAAaron M. Cook, Pharmacy Services, UKHealthcare, 800 Rose St. H109a, Lexington, KY 40536, USAGary L. Stewart, Department of Anesthesiology, UKHealthcare, 800 Rose St. H109a, Lexington, KY 40536, USABrenda G. Fahy, Department of Anesthesiology, UKHealthcare, 800 Rose St. H109a, Lexington, KY 40536, USA

Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN 1541-6933 (Source: Neurocritical Care)

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Acute Intrathecal Baclofen Withdrawal: A Brief Review of Treatment Options is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/acute-intrathecal-baclofen-withdrawal-a-brief-review-of-treatment-options.html/feed 0 GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: Reciprocal and regional interactions. http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gaba-a-and-gaba-b-receptors-mediate-feeding-elicited-by-the-gaba-b-agonist-baclofen-in-the-ventral-tegmental-area-and-nucleus-accumbens-shell-in-rats-reciprocal-and-regional-interactions.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gaba-a-and-gaba-b-receptors-mediate-feeding-elicited-by-the-gaba-b-agonist-baclofen-in-the-ventral-tegmental-area-and-nucleus-accumbens-shell-in-rats-reciprocal-and-regional-interactions.html#comments Sun, 15 Aug 2010 02:41:16 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gaba-a-and-gaba-b-receptors-mediate-feeding-elicited-by-the-gaba-b-agonist-baclofen-in-the-ventral-tegmental-area-and-nucleus-accumbens-shell-in-rats-reciprocal-and-regional-interacti GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: Reciprocal and regional interactions. is a post from: Prescription Drugs

]]> Authors: Miner P, Borkuhova Y, Shimonova L, Khaimov A, Bodnar RJ
Food intake is significantly increased following administration of GABA-B and GABA-A agonists into the nucleus accumbens (NAC) shell and ventral tegmental area (VTA) with receptor-selective antagonist pretreatment capable of blocking these responses within sites. Regional interactions in feeding studies have been evaluated by administering an antagonist in one site of interest prior to administration of the feeding-active agonist in a second site of interest, and have identified important relationships, particularly for opioid-opioid interactions. To evaluate whether regional and reciprocal VTA and NAC shell interactions occur for GABA-mediated feeding, the present study examined whether feeding elicited by the GABA-B ago…

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GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: Reciprocal and regional interactions. is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gaba-a-and-gaba-b-receptors-mediate-feeding-elicited-by-the-gaba-b-agonist-baclofen-in-the-ventral-tegmental-area-and-nucleus-accumbens-shell-in-rats-reciprocal-and-regional-interactions.html/feed 0 GABA(B) Receptor Agonism as a Novel Therapeutic Modality in the Treatment of Gastroesophageal Reflux Disease. http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gabab-receptor-agonism-as-a-novel-therapeutic-modality-in-the-treatment-of-gastroesophageal-reflux-disease.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gabab-receptor-agonism-as-a-novel-therapeutic-modality-in-the-treatment-of-gastroesophageal-reflux-disease.html#comments Tue, 03 Aug 2010 03:01:14 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gabab-receptor-agonism-as-a-novel-therapeutic-modality-in-the-treatment-of-gastroesophageal-reflux-disease.html GABA(B) Receptor Agonism as a Novel Therapeutic Modality in the Treatment of Gastroesophageal Reflux Disease. is a post from: Prescription Drugs

]]> Authors: Lehmann A, Jensen JM, Boeckxstaens GE
Defined pharmacologically by its insensitivity to the GABA(A) antagonist bicuculline and sensitivity to the GABA analogue Baclofen, the G protein-linked gamma-aminobutyric acid type B (GABA(B)) receptor couples to adenylyl cyclase, voltage-gated calcium channels, and inwardly-rectifying potassium channels. On the basis of a wealth of preclinical data in conjunction with early clinical observations that Baclofen improves symptoms of gastroesophageal reflux disease (GERD), the GABA(B) receptor has been proposed as a therapeutic target for a number of diseases including GERD. Subsequently, there has been a significant effort to develop a peripherally-restricted GABA(B) agonist that is devoid of the central nervous system side effects that are…

GABA(B) Receptor Agonism as a Novel Therapeutic Modality in the Treatment of Gastroesophageal Reflux Disease. is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gabab-receptor-agonism-as-a-novel-therapeutic-modality-in-the-treatment-of-gastroesophageal-reflux-disease.html/feed 0 GABA(B) Receptors in Addiction and Its Treatment. http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gabab-receptors-in-addiction-and-its-treatment.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gabab-receptors-in-addiction-and-its-treatment.html#comments Tue, 03 Aug 2010 03:01:14 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gabab-receptors-in-addiction-and-its-treatment.html GABA(B) Receptors in Addiction and Its Treatment. is a post from: Prescription Drugs

]]> Authors: Tyacke RJ, Lingford-Hughes A, Reed LJ, Nutt DJ
The GABA(B) receptor plays an important role in the control of neurotransmitter release, and experiments using preclinical models have shown that modulation of this receptor can have profound effects on the reward process. This ability to affect the reward process has led to clinical investigations into the possibility that this could be a viable target in the treatment of addiction. Presented here is an overview of a number of studies testing this hypothesis in different drug dependencies. The studies reviewed have used the GABA(B) receptor agonist Baclofen, which is currently the only GABA(B) agonist for use in humans. In addition, studies using the non-specific GABA(B) receptor agonists vigabatrin and tiagabine have been includ…

GABA(B) Receptors in Addiction and Its Treatment. is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gabab-receptors-in-addiction-and-its-treatment.html/feed 0 GABA-B Receptors in Drosophila. http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gaba-b-receptors-in-drosophila.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gaba-b-receptors-in-drosophila.html#comments Tue, 03 Aug 2010 03:01:14 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gaba-b-receptors-in-drosophila.html GABA-B Receptors in Drosophila. is a post from: Prescription Drugs

]]> Authors: Manev H, Dzitoyeva S
Drosophila melanogaster, the “fruit fly,” is being increasingly used as an experimental model in neurosciences, including neuropharmacology. The advantages of Drosophila over typical mammalian models in neuropharmacology include better access to genetic manipulation and the availability of almost unlimited numbers of experimental subjects at relatively low cost and with minimal regulatory restrictions. Nevertheless, one should remain cognizant of the substantial differences between insects and mammals. Insects, including Drosophila, utilize gamma-aminobutyric acid (GABA) as a neurotransmitter and express both ionotropic GABA receptors and metabotropic GABA-B receptors. Before cloning of the Drosophila GABA-B receptors (subunits 1-3), it had been assumed th…

GABA-B Receptors in Drosophila. is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/gaba-b-receptors-in-drosophila.html/feed 0 γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/hydroxybutyrate-and-the-gabaergic-footprint-a-metabolomic-approach-to-unpicking-the-actions-of-ghb.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/hydroxybutyrate-and-the-gabaergic-footprint-a-metabolomic-approach-to-unpicking-the-actions-of-ghb.html#comments Tue, 03 Aug 2010 03:01:14 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/hydroxybutyrate-and-the-gabaergic-footprint-a-metabolomic-approach-to-unpicking-the-actions-of-ghb.html γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB is a post from: Prescription Drugs

]]> J. Neurochem. (2010) 10.1111/j.1471-4159.2010.06901.x Gamma-hydroxybutyrate is found both naturally in the brain and self-administered as a drug of abuse. It has been reported to act at endogenous [gamma]-hydroxybutyrate (GHB) receptors and GABA(B) receptors [GABA(B)R], and may also be metabolized to GABA. Here, the metabolic fingerprints of a range of concentrations of GHB were measured in brain cortical tissue slices and compared with those of ligands active at GHB and GABA-R using principal components analysis (PCA) to identify sites of GHB activity. Low concentrations of GHB (1.0 [mu]M) produced fingerprints similar to those of ligands active at GHB receptors and [alpha]4-containing GABA(A)R. A total of 10 [mu]M GHB clustered proximate to mainstream GABAergic synapse ligands, such as 1…

γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/hydroxybutyrate-and-the-gabaergic-footprint-a-metabolomic-approach-to-unpicking-the-actions-of-ghb.html/feed 0 Med Sci Monit 2010; 16(8):BR260-270 "Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits" http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/med-sci-monit-2010-168br260-270-long-term-adaptation-to-high-doses-of-morphine-causes-desensitization-of-micro-or-and-delta-or-stimulated-g-protein-response-in-forebrain-cortex-but-does-not.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/med-sci-monit-2010-168br260-270-long-term-adaptation-to-high-doses-of-morphine-causes-desensitization-of-micro-or-and-delta-or-stimulated-g-protein-response-in-forebrain-cortex-but-does-not.html#comments Tue, 03 Aug 2010 03:01:14 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/med-sci-monit-2010-168br260-270-long-term-adaptation-to-high-doses-of-morphine-causes-desensitization-of-micro-or-and-delta-or-stimulated-g-protein-response-in-forebrain-cortex-but-do Med Sci Monit 2010; 16(8):BR260-270 "Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits" is a post from: Prescription Drugs

]]> Conclusions: Prolonged exposure of rats to high doses of morphine results in decrease of the over-all output of OR-stimulated G-protein activity in the forebrain cortex but does not decrease the amount of these regulatory proteins. These data support the view that the mechanism of the long-term adaptation to high doses of morphine is primarily based on desensitization of OR-response preferentially oriented to micro-OR and delta-OR. (Source: Medical Science Monitor)

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Med Sci Monit 2010; 16(8):BR260-270 "Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits" is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/med-sci-monit-2010-168br260-270-long-term-adaptation-to-high-doses-of-morphine-causes-desensitization-of-micro-or-and-delta-or-stimulated-g-protein-response-in-forebrain-cortex-but-does-not.html/feed 0 Historical Perspective and Emergence of the GABA(B) Receptor. http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/historical-perspective-and-emergence-of-the-gabab-receptor.html http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/historical-perspective-and-emergence-of-the-gabab-receptor.html#comments Tue, 03 Aug 2010 03:01:13 +0000 admin http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/historical-perspective-and-emergence-of-the-gabab-receptor.html Historical Perspective and Emergence of the GABA(B) Receptor. is a post from: Prescription Drugs

]]> Authors: Bowery NG
This chapter forms an introduction to the subsequent chapters in this volume which highlight the significance and potential therapeutic application of GABA(B) receptors. It is now 30 years since the GABA(B) site was first described in mammalian tissue. Since then much has emerged about its physiological role in the mammalian nervous system and its relationship to other neurotransmitter receptors. It appears to function at pre- and postsynaptic locations as both an auto- and a hetero-receptor where its activation modulates the membrane conductance of Ca(2+) and K(+). The receptor is G-protein coupled and was the first to be shown to exist, possibly in multiple forms, as a heterodimer. The primary agonist for the receptor is Baclofen and this continues to be used thera…

Historical Perspective and Emergence of the GABA(B) Receptor. is a post from: Prescription Drugs

]]> http://www.prescriptiondrugs2go.com/popular-drug-information/b/baclofen/historical-perspective-and-emergence-of-the-gabab-receptor.html/feed 0