Prescription Drugs 2 Go

Giving the antihistamines ranitidine or diphenhydramine to patients with perforated appendicitis dramatically increases their risk of an intra-abdominal abscess, according to a new study. Reuters Health Information (Source: Medscape Medical News Headlines)

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Conclusions  Ranitidine or diphenhydramine given to patients with perforated appendicitis may increase the risk of postoperative abscess. Therefore, these medications should not be used empirically in this population. (Source: Archives of Surgery)

This manuscript reviews the preclinical in vitro, ex vivo, and nonhuman in vivo effects of psychopharmacological agents in clinical use on cell physiology with a view toward identifying agents with neuroprotective properties in neurodegenerative disease. These agents are routinely used in the symptomatic treatment of neurodegenerative disease. Each agent is reviewed in terms of its effects on pathogenic proteins, proteasomal function, mitochondrial viability, mitochondrial function and metabolism, mitochondrial permeability transition pore development, cellular viability, and apoptosis. Effects on the metabolism of the neurodegenerative disease pathogenic proteins alpha-synuclein, beta-amyloid, and tau, …

Updated Date: Feb 2, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Updated Date: Feb 2, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Source: EMEA
Area: News
Wyeth Consumer Healthcare has notified the EMEA of its decision to withdraw its application for a centralised marketing authorisation for ibuprofen/diphenhydramine hydrochloride 200mg/25mg soft capsules, intended for use in the short-term treatment of mild to moderate pain in adults who experience sleeplessness as a result of the pain.
 
According to its official letter, the application was withdrawn based on the CHMP’s view that the data provided would not allow a positive risk-benefit balance to be concluded. 
 
A question-and-answer document and the withdrawal letter from the …

Family physicians and their patients should be aware of a massive product recall being undertaken by manufacturer McNeil Consumer Healthcare. McNeil has recalled more than 500 lots of its OTC products — including Benadryl, Rolaids, multiple variations of both Motrin and Children’s Motrin and numerous variations of Tylenol and Children’s Tylenol — because of chemical contamination. (Source: AAFP Health of the Public)

Updated Date: Jan 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Updated Date: Jan 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))