Interaction of cocaine-, benztropine-, and gbr12909-like compounds with wildtype and mutant human dopamine transporters: molecular features that differentially determine antagonist binding properties.
6 November 2009
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This study furthers the concept of using DAT mutants to differentiate cocaine-like inhibitors from atypical inhibitors in vitro. Further studies of the molecular features that define inhibitor-transporter interaction could lead to the development of DAT inhibitors with differential clinical utility.
PMID: 18786172 [PubMed - as supplied by publisher] (Source: Journal of Neurochemistry)
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