Prescription Drugs 2 Go

New evidence; conclusions changed for:
Angiotensin II receptor blockers for diastolic heart failure One RCT added comparing irbesartan versus placebo found no significant difference between irbesartan and placebo in all-cause mortality or in hospital admission for cardiovascular causes at a mean follow-up of 49.5 months. Evidence for effect of irbesartan on hospital admission for cardiovascular disease differs from evidence previously reported for candesartan for this outcome. Effects of angiotensin II receptor blockers as a class in treatment of diastolic heart failure …

Conclusions. Nebivolol in vivo activated the NO/cGMP pathway, enhanced erectile response and reversed ED in diabetic rats. Moreover, nebivolol in vitro potentiated NO/cGMP-mediated relaxation of human erectile tissues. These effects may account for the low incidence of ED in nebivolol-treated hypertensive patients. Nebivolol therefore may have utility in the treatment of ED, particularly ED associated with diabetes. Angulo J, Wright HM, Cuevas P, González-Corrochano R, Fernández A, Cuevas B, La Fuente JM, Gupta S, and de Tejada IS. Nebivolol dilates human penile arteries and reverses erectile dysfunction in diabetic rats …

Group CBT is a low-cost therapy for low-back pain with year-long benefitsRelated items from OnMedicaFalls prevention services are not evidence-basedWomen with small babies can safely wait for labourPay more heed to parent concern over sick childrenPreventative role of aspirin questionedGPs not prescribing enough Beta Blockers (Source: OnMedica Latest News)

Researchers have been able to see how heart failure affects the surface of an individual heart muscle cell in minute detail, using a new nanoscale scanning technique developed at Imperial College London. The findings may lead to better design of beta-blockers, the drugs that can slow the development of heart failure, and to improvements in current therapeutic approaches to treating heart failure and abnormal heart rhythms. Heart failure is a progressive and serious condition in which the heart is unable to supply adequate blood flow to meet the body’s …

In conclusion, increased risk of proarrhythmia, as assessed by QTc prolongation, occurs in the majority of ICU patients when prescribed medications with electrophysiologic properties. Increased vigilance is warranted. The possible protective effect of beta-blockers requires confirmation. (Source: Journal of Pharmacy Practice)

Researchers have been able to see how heart failure affects the surface of an individual heart muscle cell in minute detail, using a new nanoscale scanning technique. The findings may lead to better design of beta-blockers, the drugs that can slow the development of heart failure, and to improvements in current therapeutic approaches to treating heart failure and abnormal heart rhythms. (Source: ScienceDaily Headlines)

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Conclusions: The ESCAPE study discharge risk model and score refine risk assessment after in-hospital therapy for advanced decompensated systolic HF, allowing clinicians to focus surveillance and triage for early life-saving interventions in this high-risk population. (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness [ESCAPE]; NCT00000619) (Source: Journal of the American College of Cardiology)

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CONCLUSION. Our study shows the feasibility of preoperative CT in
aortic infective endocarditis for providing relevant data about the presence
and relationships of aortic valvular pseudoaneurysms. A larger prospective
study including a systematic comparison with transesophageal echocardiography
should be performed to determine the respective value of each technique. (Source: American Journal of Roentgenology)

Conclusions  Patients who were prescribed beta-blockers with these associated factors should be monitored more closely for antihypertensive
drug adherence.
Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00392-010-0114-1Authors
Martin C. S. Wong, Chinese University of Hong Kong School of Public Health and Primary Care, Faculty of Medicine New Territories Hong KongJohnny Y. Jiang, Chinese Academy of Medical Sciences and Peking Union Medical College DongDan SanTiao 9, DongCheng District Beijing 100730 ChinaXuefen Su, Chinese University of Hong Kong School of Public Health and Primary Care, Faculty of Medicine New Territories Hong KongHaoxiang Wang, Chinese University of …

Conclusion
Exercise test revealed a high prevalence of arrhythmias in CPVT mutation carriers diagnosed by cascade genetic screening. β-Blocker therapy appeared to suppress the most severe exercise-induced arrhythmias, while less severe arrhythmias occurred at a lower heart rate. (Source: Europace)