Prescription Drugs 2 Go

Authors: van Nuijs AL, Tarcomnicu I, Simons W, Bervoets L, Blust R, Jorens PG, Neels H, Covaci A
A sensitive hydrophilic interaction liquid chromatography (HILIC)-tandem mass spectrometry method was developed and validated for the analysis of 13 pharmaceuticals (omeprazole, pantoprazole, ranitidine, citalopram, fluoxetine, paroxetine, venlafaxine, tramadol, nebivolol, metoprolol, atenolol, Bisoprolol and metformin) in influent wastewater. The analytes were selected from the list of top-sold prescription pharmaceuticals in Belgium. The HILIC separation was optimised to achieve quantification of all analytes in real influent wastewater samples where other compounds, …

An 81-year-old woman presented with sudden-onset right-sided weakness and a global language disorder. Her medical history was notable for well-controlled hypertension, duodenal ulceration, sclerotic cataracts, a traumatic amputation of the distal phalanx of her right middle digit, and cigarette smoking. Medications on admission comprised aspirin, bendroflumethiazide, nifedipine, and Bisoprolol; no recent changes to medication had occurred. She was a retired factory worker who lived alone and, before admission, had been independent. (Source: The American Journal of Medicine)

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Conclusion
Signs and symptoms of congestion are associated with renal impairment and are independent determinants of prognosis in patients with CHF. (Source: European Journal of Heart Failure)

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CONCLUSION: Our results indicate that replacement of carvedilol for propranolol in patients with heart failure is not associated with deterioration of the ejection fraction, functional capacity, quality of life, and other cardiovascular variables related to autonomic and blood pressure control., PP.0-0). (Source: Arquivos Brasileiros de Cardiologia)

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Authors: Zhang L, Su X, Zhang C, Ouyang L, Xie Q, Ma M, Yao S
A novel method was developed for the analysis of four beta-blockers, namely sotalol, carteolol, Bisoprolol, and propranolol, in human urine by coupling carrier-mediated liquid phase microextraction (CM-LPME) to high performance liquid chromatography (HPLC). By adding an appropriate carrier in organic phase, simultaneous extraction and enrichment of hydrophilic (sotalol, carteolol, and Bisoprolol) and hydrophobic (propranolol) drugs were achieved. High enrichment factors were obtained by optimizing the compositions of the organic phase, the acceptor …

Unichem Laboratories has received US FDA approval for Bisoprolol fumarate and hydrochlorothiazide in tablet form, the drug regulator’s website showed on Friday. Both drugs are used in the treatment of hypertension. (Source: The Economic Times Healthcare and Biotech News)

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(Source: Reactions)

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Conclusions: [Delta]HR is a powerful predictor of CHF severity regardless of the presence of [beta]-blocker therapy and of [beta]-blocker daily dose. (Source: Cardiovascular Therapeutics)

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Conclusion
The beneficial effects of Bisoprolol on mortality and hospitalization for worsening heart-failure were not modified by baseline eGFRBSA. Renal impairment should not prevent the use of Bisoprolol in patients with HF. (Source: European Journal of Heart Failure)

Conclusion: Initiating therapy with Bisoprolol compared to enalapril decreased the risk of sudden death during the first year in this mild systolic CHF cohort. This was somewhat offset by an increase in pump failure deaths in the Bisoprolol-first cohort. (Source: Cardiovascular Therapeutics)

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