Prescription Drugs 2 Go

Bumex (Bumetanide) drug description – FDA approved labeling for prescription drugs and medications at RxList (Source: RxList – New and Updated Drug Monographs)

ORL 2009;71(suppl 1):10–15 (DOI:10.1159/000265114) (Source: Karger Publishers)

Conclusion: These results support the possibility that excitatory output of sevoflurane-potentiated [gamma]-aminobutyric acid type A/glycine systems may contribute to epileptogenic and neurotoxic effects in early postnatal rats.
(C) 2010 American Society of Anesthesiologists, Inc. (Source: Anesthesiology)

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Authors: Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE
Anion secretion by colonic epithelium is dependent on apical CFTR-mediated anion conductance and basolateral ion transport. In many tissues, the NKCC1 Na(+)-K(+)-2Cl(-) cotransporter mediates basolateral Cl(-) uptake. However, additional evidence suggests that the AE2 Cl(-)/HCO(3)(-) exchanger, when coupled with the NHE1 Na(+)/H(+) exchanger or a Na(+)-HCO(3)(-) cotransporter (NBC), contributes to HCO(3)(-) and/or Cl(-) uptake. To analyze the secretory functions of AE2 in proximal colon, short-circuit current (I(sc)) responses to cAMP and inhibitors of basolateral anion transporters …

The previously undescribed heterozygous missense mutation E758K was discovered in the human AE1/SLC4A1/band 3 gene in two unrelated patients with well-compensated hereditary spherostomatocytic anemia (HSt). Oocyte surface expression of AE1 E758K, in contrast to that of wild-type AE1, required coexpressed glycophorin A (GPA). The mutant polypeptide exhibited, in parallel, strong GPA dependence of DIDS-sensitive 36Cl– influx, trans-anion-dependent 36Cl– efflux, and Cl–/HCO3– exchange activities at near wild-type levels. AE1 E758K expression was also associated with GPA-dependent increases of DIDS-sensitive pH-independent SO42– uptake and oxalate uptake with altered pH dependence. In marked …

Conclusions:
Epithelial electrogenic transport is more sensitive to indomethacin in normal colonic mucosa from patients with previous or present colorectal neoplasia compared to colonic mucosa from control patients. Stimulated epithelial electrogenic transport through individual prostanoid subtype receptors EP1, EP2, EP3, and EP4 is not significantly different between neoplasia diseased patients and controls. This indicates that increased indomethacin-sensitive mechanisms in colonic mucosa from neoplasia diseased patients are not related to differences in functional expression of EP receptor subtypes. (Source: BMC Gastroenterology)

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ConclusionsNKCC1 activity is lower in erythrocytes of African Americans with essential hypertension and dyslipidemia than in Caucasian counterparts. We suggest that decreased NKCC1 may contribute to the feature of the pathogenesis of salt-sensitive hypertension seen in African Americans.American Journal of Hypertension 2009; doi:10.1038/ajh.2009.249.
PMID: 20044742 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)

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Authors: Simard JM, Kahle KT, Gerzanich V
Microvascular failure largely underlies the damaging secondary events that accompany traumatic brain injury (TBI). Changes in capillary permeability result in the extravasation of extracellular fluid, inflammatory cells, and blood, thereby producing cerebral edema, inflammation, and progressive secondary hemorrhage (PSH). Recent work in rat models of TBI and stroke have implicated 2 ion transport proteins expressed in brain endothelial cells as critical mediators of edema formation: the constitutively expressed Na(+)-K(+)-2Cl(-) cotransporter, NKCC1, and the trauma/ischemia-induced SUR1-regulated NC(Ca-ATP) (SUR1/TRPM4) channel. Whereas NKCC1 …

Conclusions: These data demonstrate that cerebral metabolism is significantly compromised during DKA, and further deterioration occurs during early DKA treatment, consistent with possible effects of cerebral hypoperfusion and “reperfusion injury”. Treatment with Bumetanide may help to diminish the adverse effects of initial treatment with insulin/saline.
PMID: 20028943 [PubMed - as supplied by publisher] (Source: Diabetes)

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The renal Bumetanide-sensitive Na-K-2Cl cotransporter (NKCC2) is the major salt transport pathway in the apical membrane of the mammalian thick ascending limb. It is differentially spliced and the three major variants (A, B, and F) differ in their localization and transport characteristics. Most knowledge about its regulation comes from experiments in Xenopus oocytes as NKCC2 proved difficult to functionally express in a mammalian system. Here we report the cloning and functional expression of untagged and unmodified versions of the major splice variants from ferret kidney (fNKCC2A, -B, and -F) in …