Prescription Drugs » B

Exenatide and Sitagliptin Not Tied to Pancreatitis

admin — Fri, 10 Sep 2010 05:40:03 +0000

Neither exenatide (Byetta) nor sitagliptin (Januvia) causes acute pancreatitis, according to a pharmacy claims analysis. Reuters Health Information (Source: Medscape Diabetes Headlines)

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Exenatide and Sitagliptin Not Tied to Pancreatitis is a post from: Prescription Drugs

After Fine, Botox Awaits Approval for Migraine

admin — Thu, 09 Sep 2010 16:40:05 +0000

Allergan will pay $600 million for its marketing tactics while the F.D.A. decides on the drugâ€™s use for migraines. (Source: NYT Health)

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After Fine, Botox Awaits Approval for Migraine is a post from: Prescription Drugs

After Fine, Botox Awaits Approval for Migraine

admin — Thu, 09 Sep 2010 16:40:04 +0000

Allergan agreed to pay $600 million for Botoxâ€™s marketing getting ahead of approved uses. But the F.D.A. will soon decide on its effectiveness for migraines. (Source: NYT)

After Fine, Botox Awaits Approval for Migraine is a post from: Prescription Drugs

Orexigen Partners With Takeda To Commercialize Obesity Drug Contrave (Naltrexone SR/Bupropion SR)

admin — Tue, 07 Sep 2010 04:00:05 +0000

Contrave (naltrexone SR/Bupropion SR), an investigational drug aimed at combination therapy to address both biological and behavioral drivers of obesity, will be developed and commercialized by Orexigen Therapeutics, Inc. and Takeda Pharmaceutical Company Limited in the USA, Canada and Mexico. The two drug firms have just signed an exclusive partnership for the North American area. The Contrave combination treatment targets the central pathways involved in controlling the balance of both food consumption and metabolism, as well as regulating eating behavior, Orexigen informs… (Source: Health News from Medical News Today)

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Orexigen Partners With Takeda To Commercialize Obesity Drug Contrave (Naltrexone SR/Bupropion SR) is a post from: Prescription Drugs

Efficacy of beta-blocker therapy in symptomatic athletes with exercise-induced intra-ventricular gradients

admin — Tue, 07 Sep 2010 03:40:08 +0000

Background:
Upright exercise stress echocardiography (SE) induces significant intraventricular gradient (IVG) and systolic anterior motion (SAM) in a large proportion of symptomatic athletes, who may therefore benefit from a negative inotropic therapy.The purpose of the present study was to assess the effect of chronic oral beta-blocker therapy on the occurrence of exercise-induced IVG and mitral valve SAM, in symptomatic athletes.
Methods:
We enrolled 35 symptomatic athletes (age: 23+-11 years) with IVG (>30 mmHg) during SE off therapy. All repeated SE on chronic oral beta-blocker therapy (atenolol up to 50 mg, Bisoprolol up to 10 mg, or metoprolol up to 100 mg daily according to physician-driven choice).
Results:
On therapy, there was during SE a reduction in IVG (35 off vs 17 on beta-bl…

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Efficacy of beta-blocker therapy in symptomatic athletes with exercise-induced intra-ventricular gradients is a post from: Prescription Drugs

Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation

admin — Tue, 07 Sep 2010 03:40:07 +0000

Conclusions: There are 21 cases of HUS following lung transplantation in the literature that may have been induced by high tacrolimus levels.Macrolides in patients taking Cyclosporin or Tacrolimus lead to high levels. Mechanism of action could be glomeruloconstrictor effect with reduced GFR increased production of Endothelin-1 and increased Platelet aggregation. (Source: Journal of Cardiothoracic Surgery) Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation is a post from: Prescription Drugs

Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation is a post from: Prescription Drugs

[Case Report] Dangers in the garden

admin — Tue, 07 Sep 2010 03:40:07 +0000

In March, 2010, a previously fit and healthy 67-year-old man presented with an 8-day history of fever with rigors, intermittent confusion, lethargy, and shortness of breath. On admission, he was febrile with a temperature of 39°C and had clinical signs of a left-sided pneumonia, accompanied by general abdominal tenderness. His white blood cell count was 14·8×109/L (number of neutrophils was 11·3×109/L, and lymphocyles 0·2×109/L), and C-reactive protein concentration was raised at 475 mg/L. Renal, and liver function were abnormal: urea concentration was 21·6 mmol/L; creatinine 257 μmol/L; sodium 135 mmol/L; potassium 4 mmol/L; aspartate aminotransferase 115 IU/L; alanine aminotransferase 80 IU/L; and bilirubin 56 μmol/L. A chest radiograph showed complete opacification of his left…

[Case Report] Dangers in the garden is a post from: Prescription Drugs

Clarithromycin attenuates autophagy in myeloma cells.

admin — Tue, 07 Sep 2010 03:40:07 +0000

Authors: Nakamura M, Kikukawa Y, Takeya M, Mitsuya H, Hata H
It has been reported that clarithromycin (CAM) augments the anti-tumor activity of thalidomide against multiple myeloma (MM) cells, while the mechanism remains unclear. A myeloma cell line or primary myeloma cells were treated with CAM. Autophagy was analyzed by morphological changes, LC3 expression and lysotracker staining. CAM induced vacuoles in the cytoplasm of MM cells which resembled autolysosomes. The manifestation of the CAM-induced vacuoles was blocked by treatment with PI3-kinase inhibitor. CAM induced an accumulation of LC3-II without affecting the mTOR or AKT pathways, eventually leading to cell death. CAM may halt the autophagy process after fusion of autophagosomes with lysosomes. This phenomenon may explain how…

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Clarithromycin attenuates autophagy in myeloma cells. is a post from: Prescription Drugs

Efficacy of the combination of tobramycin and a macrolide in an in vitro mature biofilm model of Pseudomonas aeruginosa.

admin — Tue, 07 Sep 2010 03:40:06 +0000

Authors: TrÃ©-Hardy M, Nagant C, El Manssouri N, Vanderbist F, Traore H, Vaneechoutte M, Dehaye JP
Respiratory disease is the main cause of morbidity and mortality in patients with cystic fibrosis (CF), In particular, patients suffer from chronic infection due biofilm formation by opportunistic Pseudomonas aeruginosa(32). Therefore, there is an urgent need to develop alternative ways to treat biofilm associated clinical infections. The aim of this study was to compare the antimicrobial effect in vitro of the combination tobramycin/clarithromycin versus tobramycin/azithromycin against five P. aeruginosa biofilms and to establish the most effective combination. We performed a kinetic study over a period of 28 days of a twice daily co-administration of the combinations tobramycin/clarit…

Efficacy of the combination of tobramycin and a macrolide in an in vitro mature biofilm model of Pseudomonas aeruginosa. is a post from: Prescription Drugs

Activity of high dose daptomycin, vancomycin and moxifloxacin alone or in combination with clarithromycin or rifampin in a novel in vitro model of Staphylococcus aureus biofilm.

admin — Tue, 07 Sep 2010 03:40:06 +0000

In conclusion, we developed a novel in-vitro PK/PD model to assess the activity of antimicrobials against mature bacterial biofilm. Combinations of DAP or MOX with CLA were the most effective regimens and may represent promising options to treat persistent infections caused by S. aureus biofilms. PMID: 20696880 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy) Activity of high dose daptomycin, vancomycin and moxifloxacin alone or in combination with clarithromycin or rifampin in a novel in vitro model of Staphylococcus aureus biofilm. is a post from: ...

Activity of high dose daptomycin, vancomycin and moxifloxacin alone or in combination with clarithromycin or rifampin in a novel in vitro model of Staphylococcus aureus biofilm. is a post from: Prescription Drugs