Prescription Drugs 2 Go

CONCLUSION: ACE inhibitors, such as Captopril, may be applied as important compounds for MMP-2 inhibition in inflammation caused by CAPD.
PMID: 20184869 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)

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Gohel M C, Nagori S AIndian Journal of Pharmaceutical Sciences 2009 71(6):622-629The aim of present study were to arrest the problem of content uniformity without the use of harmful organic solvent and to improve <i>ex vivo</i> permeability of Captopril, a low dose class III drug as per biological classification system. Eutectic mixture of camphor and menthol was innovatively used in the work. Captopril solution in eutectic mixture was blended with Avicel PH 102 and then the mixture was blended with mannitol in different ratios. Formulated batches were characterized for angle …

Abstract  Primary aldosteronism (PA) has long been considered a rare disease, but a higher prevalence was suggested recently. The aim
of this study was to evaluate the prevalence of PA in a group of Bulgarian hypertensive patients, including patients with
adrenal incidentalomas (AI). The aldosterone to renin ratio (ARR)>750 was used as a positive screening test and the Captopril
test was performed to confirm the diagnosis. Adrenal CT scan was used to differentiate between the main subtypes of PA-aldosterone-producing
adenoma (APA) and idiopathic hyperaldosteronism (IHA). The diagnosis of APA was retrospectively …

Horm Metab ResDOI: 10.1055/s-0029-1246186AbstractPrimary aldosteronism is the most common form of secondary hypertension and patients with hyperaldosteronism are more prone to premature cardiovascular complications compared to essential hypertensives. The diagnostic flow-chart for the diagnosis of PA is performed in three steps: a) screening; b) confirmation; and c) subtype differentiation. Instead of proceeding directly to subtype classification, the recently published Endocrine Society Guidelines recommend that patients with a positive ARR should undergo a confirmatory test, in order to definitively confirm or exclude the diagnosis of PA. The Guidelines recognize four testing …

In segments of human varicose veins, endothelial function was assessed by measuring relaxation induced by acetylcholine in noradrenaline-precontracted preparations. In addition, concentration-response curves to acetylcholine were obtained before and after incubation with the arterial endothelium protectant agents Captopril, losartan, troglitazone, pravastatin, or simvastatin. The antivaricose agent escin was also tested. Mean acetylcholine-induced relaxation of varicose venous rings was about 13%, approximately one third of that reported for control saphenous veins. Concentration-response curves to acetylcholine were ‘‘u’’ shaped, the result of endothelium-mediated relaxation at low concentrations, superseded by subsequent smooth muscle …

A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on the reaction with iminoquinone radical produced from the N,N-dimethyl-p-phenilenediamene (DMPD) oxidation in acid medium. The reagents addition order was evaluated and analytical parameters were optimized. The linear concentrations ranges were 2.5-90 and 5.0-50 mg L-1 for CPT and NAC, respectively. Limits of detection (3σ) were calculated at 0.22 and 1.8 mg L-1 and the relative standard deviation (N = 10) were lower than 1.0 and 2.1% for CPT and NAC, respectively. …

Authors: Albuquerque D, Nihei J, Cardillo F, Singh R
Increasing evidence implies beneficial effects of angiotensin-converting enzyme (ACE) inhibitors beyond those of their original indications to control hypertension. One of the most attractive non-hemodynamic properties of ACE inhibitors is their ability to regulate cytokine production. The mechanism(s) underlying the role of ACE inhibitors on cytokine synthesis are not well understood but they have traditionally been attributed to the inhibition of angiotensin (Ang) II formation. In fact, it has been extensively demonstrated that ACE inhibitors decrease Ang II-induced …

(Source: Reactions)

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Updated Date: Dec 29, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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We examined the role of ADAMTS-1 in the antifibrotic activity of the ACE inhibitor Captopril in a chronic viral myocarditis (CVMC) model. Balb/c mice were assigned to five groups: normal control group1 (group 1) , normal control group2 (group 2), CVMC model group(group 3), CVMC control group (group 4) and Captopril therapy group (group 5) . Group 3, 4 and 5 received Coxsackievirus B(3) to induce CVMC and group 5 was treated with Captopril (100mg/kg )for 28days. Heart sections were stained with picrosirius red and collagen volume fraction calculated. ADAMTS-1 …