Prescription Drugs 2 Go

Source: DARE
Area: Evidence > Disease Focused Reviews
CRD Summary: This review evaluated the effect of angiotensin-converting enzyme-inhibitor or angiotensin receptor blocker use following kidney transplantation. The authors found that treatment with an angiotensin-converting enzyme-inhibitor or angiotensin receptor blocker produced clinically conflicting results of reductions in proteinuria, haematocrit and glomerular filtration rate in renal transplant recipients. These conclusions seemed sufficiently cautious.
[The included interventions were benazapril, candesartan, Captopril, enalapril, fosinopril, lisinopril, losartan, perindopril, quinapril, trandolapril and valsartan.]
CRD Commentary: The research question was clear with supporting inclusion criteria for participants, interven…

MedWorm …

This study was accompanied by an evaluation of adverse
effects of combined treatment with Captopril and antiepileptic drugs in the passive avoidance task and chimney test. Captopril
(25 and 50 mg/kg i.p.) did not influence the threshold for electroconvulsions. Among the tested antiepileptics, Captopril
(25 and 50 mg/kg i.p.) potentiated the antiseizure action of CBZ, decreasing its ED50 value from 12.1 to 8.9 and 8.7 mg/kg, respectively. Moreover, Captopril (50 mg/kg i.p.) enhanced the anticonvulsant activity
of LTG. ED50 value for LTG was lowered from 5.1 to 3.5 mg/kg. The observed interactions between Captopril and …

Conclusions : The above results suggest that the methanol/methylene chloride extract of the stem bark of M. africana may protect kidney against renal dysfunction and further demonstrate that its antihypertensive effect does not depend on a diuretic or natriuretic activity. (Source: Indian Journal of Pharmacology)

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Abstract  The present study was designed to investigate the effects of Captopril, an angiotensin-converting enzyme inhibitor (ACEI),
on bone loss in aged ovariectomized (OVX) rats and its impact on the differentiation of cultured primary osteoblasts. Ten-month-old
female Sprague–Dawley rats were used for the study. After 2 months post ovariectomy (OVX), the rats were treated with Captopril
(1 or 5 mg/kg/day, respectively) for another 2 months. At endpoint, trabecular bone of the fourth lumbar vertebrae (L4) was
undecalcified and examined by bone histomorphometry; the fifth lumbar vertebrae (L5) were examined by compression test. Primary
osteoblasts …

Background:
Activation of glucagon-like peptide-1 (GLP-1) receptors improves insulin sensitivity and induces vasodilatation and diuresis. AC3174 is a peptide analogue with pharmacologic properties similar to the GLP-1 receptor agonist, exenatide. Hypothetically, chronic AC3174 treatment could attenuate salt-induced hypertension, cardiac morbidity, insulin resistance, and renal dysfunction in Dahl salt-sensitive (DSS) rats.
Methods:
DSS rats were fed low salt (LS, 0.3% NaCl) or high salt (HS, 8% NaCl) diets. HS rats were treated with vehicle, AC3174 (1.7 pmol/kg/min), or GLP-1 (25 pmol/kg/min) for 4 weeks via subcutaneous infusion. Other HS rats received Captopril (150 mg/kg/day) …

Cardiology 2010;116:194–205 (DOI:10.1159/000315146) (Source: Karger Publishers)

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Authors: Green T, Rodriguez J, Navar LG
NSAID usage has long revealed renoprotective prostaglandin actions on the renal microvasculature during increased pressor hormone influence, but whether increased COX-2 expression supports prostaglandin vasodilatory influence by interfering with the actions of angiotensin II (AngII) remains unresolved. Therefore, we tested the hypothesis that COX-2 inhibition causes hemodynamic and excretory effects that are increased in proportion to AngII activity. In anesthetized Sprague-Dawley rats having augmented cortical COX-2 expression but different AngII activity, we conducted renal clearance experiments during acute inhibition of …

Authors: John S Smeda
& Noriko Daneshtalab (Source: Journal of Cerebral Blood Flow)

CONCLUSIONS: Captopril induced a decrease in the GFR that could be quantitatively measured with 51Cr-EDTA. The reduction is more pronounced in hypertensive patients with RAS. (Source: Clinics)

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Many experimental and clinical studies suggest a relationship between enhanced angiotensin II release by the angiotensin-converting enzyme (ACE) and the pathophysiology of atherosclerosis. The atherosclerosis-enhancing effects of angiotensin II are complex and incompletely understood. To identify anti-atherogenic target genes, we performed microarray gene expression profiling of the aorta during atherosclerosis prevention with the ACE inhibitor, Captopril. Atherosclerosis-prone apolipoprotein E (apoE)-deficient mice were used as a model to decipher susceptible genes regulated during atherosclerosis prevention with Captopril. Microarray gene expression profiling and immunohistology revealed that Captopril treatment for 7 months strongly …