Prescription Drugs » Captopril

(E)-N-[(3,4-dimethoxyphenethyl)]-N-methyl-3-(3-pyridyl)-2-propenamide (TJN-331) inhibits mesangial expansion in experimental IgA nephropathy in ddY mice

admin — Fri, 10 Sep 2010 07:40:15 +0000

Conclusion These results suggest that TJN-331 is effective against IgA nephropathy in ddY mice and acts via suppression of TGF-Î²1 production
in glomeruli.

Content Type Journal ArticleDOI 10.1007/s10157-010-0338-4Authors
Yayoi Saegusa, Division of Pharmasciences, Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, N12 W6, Kita-ku, Sapporo, 060-0812 JapanChiharu Sadakane, Division of Pharmasciences, Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, N12 W6, Kita-ku, Sapporo, 060-0812 JapanJunichi Koseki, Tsumura & Co., Tsumura Research Laboratories, 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-1192 JapanYoshihiro Hasegawa, Tsumura & Co., Tsumura Research…

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(E)-N-[(3,4-dimethoxyphenethyl)]-N-methyl-3-(3-pyridyl)-2-propenamide (TJN-331) inhibits mesangial expansion in experimental IgA nephropathy in ddY mice is a post from: Prescription Drugs

Renin angiotensin system blockade in kidney transplantation: a systematic review of the evidence

admin — Thu, 26 Aug 2010 07:40:04 +0000

Source: DARE
Area: Evidence > Disease Focused Reviews
CRD Summary: This review evaluated the effect of angiotensin-converting enzyme-inhibitor or angiotensin receptor blocker use following kidney transplantation. The authors found that treatment with an angiotensin-converting enzyme-inhibitor or angiotensin receptor blocker produced clinically conflicting results of reductions in proteinuria, haematocrit and glomerular filtration rate in renal transplant recipients. These conclusions seemed sufficiently cautious.
[The included interventions were benazapril, candesartan, Captopril, enalapril, fosinopril, lisinopril, losartan, perindopril, quinapril, trandolapril and valsartan.]
CRD Commentary: The research question was clear with supporting inclusion criteria for participants, interven…

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Renin angiotensin system blockade in kidney transplantation: a systematic review of the evidence is a post from: Prescription Drugs

Captopril potentiates the anticonvulsant activity of carbamazepine and lamotrigine in the mouse maximal electroshock seizure model

admin — Fri, 20 Aug 2010 09:00:20 +0000

This study was accompanied by an evaluation of adverse
effects of combined treatment with Captopril and antiepileptic drugs in the passive avoidance task and chimney test. Captopril
(25 and 50 mg/kg i.p.) did not influence the threshold for electroconvulsions. Among the tested antiepileptics, Captopril
(25 and 50 mg/kg i.p.) potentiated the antiseizure action of CBZ, decreasing its ED50 value from 12.1 to 8.9 and 8.7 mg/kg, respectively. Moreover, Captopril (50 mg/kg i.p.) enhanced the anticonvulsant activity
of LTG. ED50 value for LTG was lowered from 5.1 to 3.5 mg/kg. The observed interactions between Captopril and CBZ or LTG were pharmacodynamic
in nature as Captopril did not alter plasma and total brain concentrations of these antiepileptics. The combinati…

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Captopril potentiates the anticonvulsant activity of carbamazepine and lamotrigine in the mouse maximal electroshock seizure model is a post from: Prescription Drugs

Renal effects of Mammea africana Sabine (Guttiferae) stem bark methanol/methylene chloride extract on L-NAME hypertensive rats

admin — Sun, 15 Aug 2010 07:40:03 +0000

Conclusions : The above results suggest that the methanol/methylene chloride extract of the stem bark of M. africana may protect kidney against renal dysfunction and further demonstrate that its antihypertensive effect does not depend on a diuretic or natriuretic activity. (Source: Indian Journal of Pharmacology) MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising. Renal effects of Mammea africana Sabine (Guttiferae) stem bark methanol/methylene chloride extract on L-NAME hypertensive rats is a post from: Prescription Drugs

Renal effects of Mammea africana Sabine (Guttiferae) stem bark methanol/methylene chloride extract on L-NAME hypertensive rats is a post from: Prescription Drugs

Captopril improves osteopenia in ovariectomized rats and promotes bone formation in osteoblasts

admin — Tue, 10 Aug 2010 10:00:05 +0000

Abstract The present study was designed to investigate the effects of Captopril, an angiotensin-converting enzyme inhibitor (ACEI),
on bone loss in aged ovariectomized (OVX) rats and its impact on the differentiation of cultured primary osteoblasts. Ten-month-old
female Spragueâ€“Dawley rats were used for the study. After 2 months post ovariectomy (OVX), the rats were treated with Captopril
(1 or 5 mg/kg/day, respectively) for another 2 months. At endpoint, trabecular bone of the fourth lumbar vertebrae (L4) was
undecalcified and examined by bone histomorphometry; the fifth lumbar vertebrae (L5) were examined by compression test. Primary
osteoblasts were isolated from the calvaria of newborn rats and treated with different concentrations of Captopril in a dif…

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Captopril improves osteopenia in ovariectomized rats and promotes bone formation in osteoblasts is a post from: Prescription Drugs

The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats

admin — Tue, 03 Aug 2010 13:00:05 +0000

Background:
Activation of glucagon-like peptide-1 (GLP-1) receptors improves insulin sensitivity and induces vasodilatation and diuresis. AC3174 is a peptide analogue with pharmacologic properties similar to the GLP-1 receptor agonist, exenatide. Hypothetically, chronic AC3174 treatment could attenuate salt-induced hypertension, cardiac morbidity, insulin resistance, and renal dysfunction in Dahl salt-sensitive (DSS) rats.
Methods:
DSS rats were fed low salt (LS, 0.3% NaCl) or high salt (HS, 8% NaCl) diets. HS rats were treated with vehicle, AC3174 (1.7 pmol/kg/min), or GLP-1 (25 pmol/kg/min) for 4 weeks via subcutaneous infusion. Other HS rats received Captopril (150 mg/kg/day) or AC3174 plus Captopril.
Results:
HS rat survival was improved by all treatments except GLP-1. Systolic blood p…

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The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats is a post from: Prescription Drugs

Myocardial Calcification and Hypertension following Chronic Renal Failure and Ameliorative Effects of Furosemide and Captopril

admin — Mon, 02 Aug 2010 07:41:20 +0000

Cardiology 2010;116:194Ã¢Â€Â“205 (DOI:10.1159/000315146) (Source: Karger Publishers) MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising. Myocardial Calcification and Hypertension following Chronic Renal Failure and Ameliorative Effects of Furosemide and Captopril is a post from: Prescription Drugs

Myocardial Calcification and Hypertension following Chronic Renal Failure and Ameliorative Effects of Furosemide and Captopril is a post from: Prescription Drugs

Augmented Cyclooxygenase-2 Effects on Renal Function During Varying States of Angiotensin II Activity.

admin — Mon, 02 Aug 2010 07:40:06 +0000

Authors: Green T, Rodriguez J, Navar LG
NSAID usage has long revealed renoprotective prostaglandin actions on the renal microvasculature during increased pressor hormone influence, but whether increased COX-2 expression supports prostaglandin vasodilatory influence by interfering with the actions of angiotensin II (AngII) remains unresolved. Therefore, we tested the hypothesis that COX-2 inhibition causes hemodynamic and excretory effects that are increased in proportion to AngII activity. In anesthetized Sprague-Dawley rats having augmented cortical COX-2 expression but different AngII activity, we conducted renal clearance experiments during acute inhibition of COX-2 with nimesulide (NMSLD) and COX-1 with SC-560. One series received acute Captopril either alone (aACEi; n=13) or in co…

Augmented Cyclooxygenase-2 Effects on Renal Function During Varying States of Angiotensin II Activity. is a post from: Prescription Drugs

The effects of poststroke captopril and losartan treatment on cerebral blood flow autoregulation in SHRsp with hemorrhagic stroke

admin — Sun, 25 Jul 2010 07:40:04 +0000

Authors: John S Smeda & Noriko Daneshtalab (Source: Journal of Cerebral Blood Flow) The effects of poststroke captopril and losartan treatment on cerebral blood flow autoregulation in SHRsp with hemorrhagic stroke is a post from: Prescription Drugs

The effects of poststroke captopril and losartan treatment on cerebral blood flow autoregulation in SHRsp with hemorrhagic stroke is a post from: Prescription Drugs

Glomerular filtration rate measured by 51Cr-EDTA clearance: evaluation of captopril-induced changes in hypertensive patients with and without renal artery stenosis

admin — Sun, 25 Jul 2010 07:40:04 +0000

CONCLUSIONS: Captopril induced a decrease in the GFR that could be quantitatively measured with 51Cr-EDTA. The reduction is more pronounced in hypertensive patients with RAS. (Source: Clinics) MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising. Glomerular filtration rate measured by 51Cr-EDTA clearance: evaluation of captopril-induced changes in hypertensive patients with and without renal artery stenosis is a post from: Prescription Drugs

Glomerular filtration rate measured by 51Cr-EDTA clearance: evaluation of captopril-induced changes in hypertensive patients with and without renal artery stenosis is a post from: Prescription Drugs