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Authors: Papagiannouli F, Mechler BM
Gamete development requires a coordinated soma-germ line interaction that ensures renewal and differentiation of germline and somatic stem cells. The physical contact between the germline and somatic cell populations is crucial because it allows the exchange of diffusible signals among them. The tumor suppressor gene discs large (dlg) encodes a septate junction protein with functions in epithelial cell polarity, asymmetric neuroblast division and formation of neuromuscular junctions. Our recent work reveals a new role of dlg in the Drosophila testis, as mutations …

This article explores the metaphor through an analysis of the changing aetiological accounts of personality disorders associated with antisocial behaviour advanced in the American Journal of Psychiatry from 1950 onwards. It is argued that the social, scientific and economic factors which help shape overarching professional trends in psychiatry only partly structure personality disorder discourse. If the pendulum swings, therefore, not all psychiatrists move with it. (Source: History of Psychiatry)

A thorough understanding of the circadian clock requires qualitative evaluation of circadian clock gene expression. Thus far, no simple and… (Source: Proceedings of the National Academy of Sciences)

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Author Summary
The On-Off direction-selective ganglion cell (DSGC) found in mammalian retinas generates a directional signal, responding most strongly to a stimulus moving in a specific direction. The DSGC initiates spikes in its dendritic tree which are thought to propagate to the soma and brain with high probability. Both dendritic and somatic spikes in the DSGC display strong directional tuning, whereas postsynaptic potentials (PSPs) recorded in the soma are only weakly directional, indicating that postsynaptic spike generation markedly enhances the directional signal. We constructed a realistic computational model to determine the …

The Gambia Committee on Harmful Traditional Practices (GAMCOTRAP), recently held a day’s sensitisation forum for the Traditional Birth Attendants (TBAs) and female circumcisers at Kaira Konko in Soma, Lower River Region (LRR). (Source: AllAfrica News: Health and Medicine)

Conclusion:
Our work shows that ephrinA5 protein is expressed in restrictive regions of the developing mouse brain. This expression pattern points out the potential sites of action of this molecule in the olfactory, retinotectal, thalamocortical, corticothalamic and mesostriatal systems, during development. This study is essential to better understand the role of ephrinA5 during developmental topographic mapping of connections and to further characterise the mechanisms involved in pathway restoration following cell transplantation in the damaged brain. (Source: BMC Neuroscience – Latest articles)

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GAMCOTRAP has concluded consultation with Local Government Authorities including National Women Councillors on advocacy for law on Female Genital Mutilation – FGM as well as a sensitisation workshop with Circumcisers, traditional Birth Attendants and Women leaders at Kaira Konko in Soma, Lower River Region. (Source: AllAfrica News: Health and Medicine)

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Authors: Merriam LA, Locknar SA, Girard BM, Parsons RL
Prior studies indicated that a Ca(2+)-dependent release of ATP can be initiated from the soma of sympathetic neurons dissociated from guinea pig stellate ganglia. Previous studies also indicated that Ca(2+)-induced Ca(2+) release (CICR) can modulate membrane excitability in these same neurons. As Ca(2+) release from internal stores is thought to support somatodendritic transmitter release in other neurons, the present study investigated whether CICR is essential for somatic ATP release from dissociated sympathetic neurons. Caffeine increased intracellular Ca(2+) ([Ca(2+)](i)) …

In conclusion, the calbindin-immunoreactive cells in the sculpin differ from mammalian IPANs with regard to several parameters and future functional studies could hopefully add information about the role of this large group of cells in the fish enteric nervous system.
PMID: 20674511 [PubMed - as supplied by publisher] (Source: Autonomic Neuroscience)

Epigenetic mechanisms are thought to help regulate the unique transcription program that is established in germ cell development. During the germline cycle of many organisms, the epigenome undergoes waves of extensive resetting events, while a part of epigenetic modification remains faithful to specific loci. Little is known about the mechanisms underlying these events, how loci are selected for, or avoid, reprogramming, or even why these events are required. In particular, although the significance of genomic imprinting phenomena involving DNA methylation in mammals is now well accepted, the role of histone …