Prescription Drugs 2 Go

Conclusions: Those findings indicate that a low dose of celecoxib could augment CDDP-induced growth inhibition of Tca8113 cells and its xenograft in Balb/c nude mice. (Source: Journal of Oral Pathology and Medicine)

Mr. Gilgore, an opera lover, had roles in the advancement of drugs like Ambien and celebrex. (Source: NYT > Health)

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Abstract  Hemicrania continua (HC) and new daily-persistent headache (NDPH) represent the only two forms of chronic daily headache in
Chap. IV “Other Primary Headaches” of the second edition of the International Classification of Headache Disorders. HC and
NDPH are rare and poorly defined from a pathophysiological point of view; as a consequence, their management is largely empirical.
Indeed, there is a lack of prospective, controlled trials in this field, and treatment effectiveness is basically inferred
from the results of sparse open-label trials, retrospective case series, clinical experience and expert opinions. In …

Interleukin-12 (IL-12), p80, and IL-23 are structurally related cytokines sharing a p40 subunit. We have recently demonstrated that celecoxib and its COX-2-independent analogue 4-trifluoromethyl-celecoxib (TFM-C) inhibit secretion but not transcription of IL-12 (p35/p40) and p80 (p40/p40). This is associated with a mechanism involving altered cytokine-chaperone interaction in the endoplasmic reticulum (ER). In the present study, we found that celecoxib and TFM-C also block secretion of IL-23 (p40/p19 heterodimers). Given the putative ER-centric mode of these compounds, we performed a comprehensive RT-PCR analysis of 23 ER-resident chaperones/foldases and associated co-factors. This …

Elevated interleukin (IL)-1 concentrations in synovial fluid have been implicated in joint bone and cartilage destruction. Previously, we showed that IL-1β stimulated the expression of prostaglandin (PG) receptor EP4 via increased PGE2 production. However, the effect of IL-1β on osteoclast formation via chondrocytes is unclear. Therefore, we examined the effect of IL-1β and/or celecoxib on the expression of macrophage colony-stimulating factor (M-CSF), receptor activator of NF-κB ligand (RANKL), and osteoprotegerin (OPG) in human chondrocytes, and the indirect effect of IL-1β on osteoclast-like cell formation using RAW264.7 cells. OPG and RANKL …

BOSTON – A former member of Pfizer Inc.’s speakers’ bureau pleaded guilty Feb. 22 to health care fraud for falsifying data in support of a published study on pain management, according to documents filed in the U.S. District Court for the District of Massachusetts (United States of America v. Scott Reuben, No. 10-30002, D. Mass.; See January 2010, Page 4).
Full story on lexis.com (Source: LexisNexis® Mealey’s™ Arthritis Drugs Legal News)

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BOSTON (AP) — A doctor accused of faking research for a dozen years in published studies that suggested after-surgery benefits from painkillers including Vioxx and celebrex pleaded guilty Monday to one count of federal health care fraud.
An… (Source: OrlandoSentinel: Medical Research)

CONCLUSIONS: Exemestane reduces proliferation in ER-positive DCIS. Aromatase inhibition is a potential alternative to tamoxifen in patients who have undergone breast conservation for ER-positive DCIS. Clin Cancer Res; 16(5); 1605-12.
PMID: 20179229 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Contrary to previous hypotheses, the use of non-steroidal anti-inflammatory drugs does not appear associated with risk of squamous cell skin cancer, according to a report posted online today that will appear in the April print issue of Archives of Dermatology, one of the JAMA/Archives journals. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen and celecoxib reduce pain and inflammation by blocking an enzyme involved in producing inflammatory compounds, according to background information in the article… (Source: Health News from Medical News Today)