Prescription Drugs » Chantix

Primary resistance to clarithromycin, metronidazole and amoxicillin of Helicobacter pylori isolated from Tunisian patients with peptic ulcers and gastritis: a prospective multicentre study.

admin — Tue, 07 Sep 2010 07:40:08 +0000

Conclusion:
local data regarding the primary resistance of H. pylori to clarithromycin, metronidazole and amoxicillin and the main genetic mutation involved in clarithromycin resistance in vivo (A2143G) are necessary to prove a clear need for a periodic evaluation of antibiotic consumption and new therapeutic strategies in Tunisia in order to avoid the emergence of resistant strains. (Source: Annals of Clinical Microbiology and Antimicrobials)

Primary resistance to clarithromycin, metronidazole and amoxicillin of Helicobacter pylori isolated from Tunisian patients with peptic ulcers and gastritis: a prospective multicentre study. is a post from: Prescription Drugs

[Review] Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

admin — Tue, 07 Sep 2010 07:40:08 +0000

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are generally thought to have high mortality rates. However, many cases can be treated with the right combination and rational use of available antituberculosis drugs. This Review describes the evidence available for each drug and discusses the basis for recommendations for the treatment of patients with MDR and XDR tuberculosis. The recommended regimen is the combination of at least four drugs to which the Mycobacterium tuberculosis isolate is likely to be susceptible. Drugs are chosen with a stepwise selection process through five groups on the basis of efficacy, safety, and cost. Among the first group (the oral first-line drugs) high-dose isoniazid, pyrazinamide, and ethambutol are thought of as an adjunct for t…

MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising.

[Review] Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis is a post from: Prescription Drugs

Review: Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

admin — Tue, 07 Sep 2010 07:40:08 +0000

Source: Lancet Infectious Diseases
Area: News
In this review, the authors discuss the evidence that rational use of antituberculosis drugs can treat multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. The following drugs groups are covered:

. Group one- first-line antituberculosis drugs: isoniazid, rifampicin and others rifamycins, pyrazinamide, ethambutol.

. Group two- fluoroquinolones: ciprofloxacin, ofloxacin, levofloxacin, and moxifloxacin.

. Group three- injectable antituberculosis drugs: aminoglycosides (streptomycin, kanamycin, and amikacin) and the polypeptides (capreomycin and viomycin)

. Group four- second-line antituberculosis drugs: thioamides (ethionamide and protionamide), cycloser…

Review: Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis is a post from: Prescription Drugs

A fatal Mycobacterium chelonae infection in an immunosuppressed patient with systemic lupus erythematosus and concomitant Fahr’s syndrome

admin — Tue, 07 Sep 2010 07:40:08 +0000

We present a case of systemic Mycobacterium chelonae infection in an immunosuppressed patient with systemic lupus erythematosus (SLE), idiopathic hypoparathyroidism, and hypothyroidism.
The patient was treated for 3 months for skin infection with clarithromycin monotherapy. Since her condition deteriorated,
the antibiotic therapy was switched to intravenously administered clindamycin, cloxacillin, and meropenem. Due to further
deterioration and isolation of M. chelonae from the blood culture, antimicrobial therapy was changed to azithromycin and amikacin. Drug-test sensitivity was performed,
and the isolate was susceptible to clarithromycin only. The patient’s deteriorating status prevented orally administered medication
with clarithromycin (parenteral formulation is not registered …

A fatal Mycobacterium chelonae infection in an immunosuppressed patient with systemic lupus erythematosus and concomitant Fahr’s syndrome is a post from: Prescription Drugs

Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation

admin — Tue, 07 Sep 2010 07:40:08 +0000

Conclusions:
There are 21 cases of HUS following lung transplantation in the literature that may have been induced by high tacrolimus levels.Macrolides in patients taking Cyclosporin or Tacrolimus lead to high levels. Mechanism of action could be glomeruloconstrictor effect with reduced GFR increased production of Endothelin-1 and increased Platelet aggregation. (Source: Journal of Cardiothoracic Surgery)

Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation is a post from: Prescription Drugs

[Case Report] Dangers in the garden

admin — Tue, 07 Sep 2010 07:40:08 +0000

In March, 2010, a previously fit and healthy 67-year-old man presented with an 8-day history of fever with rigors, intermittent confusion, lethargy, and shortness of breath. On admission, he was febrile with a temperature of 39°C and had clinical signs of a left-sided pneumonia, accompanied by general abdominal tenderness. His white blood cell count was 14·8×109/L (number of neutrophils was 11·3×109/L, and lymphocyles 0·2×109/L), and C-reactive protein concentration was raised at 475 mg/L. Renal, and liver function were abnormal: urea concentration was 21·6 mmol/L; creatinine 257 μmol/L; sodium 135 mmol/L; potassium 4 mmol/L; aspartate aminotransferase 115 IU/L; alanine aminotransferase 80 IU/L; and bilirubin 56 μmol/L. A chest radiograph showed complete opacification of his left…

[Case Report] Dangers in the garden is a post from: Prescription Drugs

Clarithromycin attenuates autophagy in myeloma cells.

admin — Tue, 07 Sep 2010 07:40:08 +0000

Authors: Nakamura M, Kikukawa Y, Takeya M, Mitsuya H, Hata H
It has been reported that clarithromycin (CAM) augments the anti-tumor activity of thalidomide against multiple myeloma (MM) cells, while the mechanism remains unclear. A myeloma cell line or primary myeloma cells were treated with CAM. Autophagy was analyzed by morphological changes, LC3 expression and lysotracker staining. CAM induced vacuoles in the cytoplasm of MM cells which resembled autolysosomes. The manifestation of the CAM-induced vacuoles was blocked by treatment with PI3-kinase inhibitor. CAM induced an accumulation of LC3-II without affecting the mTOR or AKT pathways, eventually leading to cell death. CAM may halt the autophagy process after fusion of autophagosomes with lysosomes. This phenomenon may explain how…

MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising.

Clarithromycin attenuates autophagy in myeloma cells. is a post from: Prescription Drugs

Efficacy of beta-blocker therapy in symptomatic athletes with exercise-induced intra-ventricular gradients

admin — Tue, 07 Sep 2010 07:40:08 +0000

Background:
Upright exercise stress echocardiography (SE) induces significant intraventricular gradient (IVG) and systolic anterior motion (SAM) in a large proportion of symptomatic athletes, who may therefore benefit from a negative inotropic therapy.The purpose of the present study was to assess the effect of chronic oral beta-blocker therapy on the occurrence of exercise-induced IVG and mitral valve SAM, in symptomatic athletes.
Methods:
We enrolled 35 symptomatic athletes (age: 23+-11 years) with IVG (>30 mmHg) during SE off therapy. All repeated SE on chronic oral beta-blocker therapy (atenolol up to 50 mg, Bisoprolol up to 10 mg, or metoprolol up to 100 mg daily according to physician-driven choice).
Results:
On therapy, there was during SE a reduction in IVG (35 off vs 17 on beta-bl…

MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising.

Efficacy of beta-blocker therapy in symptomatic athletes with exercise-induced intra-ventricular gradients is a post from: Prescription Drugs

Orexigen Partners With Takeda To Commercialize Obesity Drug Contrave (Naltrexone SR/Bupropion SR)

admin — Tue, 07 Sep 2010 07:40:08 +0000

Contrave (naltrexone SR/Bupropion SR), an investigational drug aimed at combination therapy to address both biological and behavioral drivers of obesity, will be developed and commercialized by Orexigen Therapeutics, Inc. and Takeda Pharmaceutical Company Limited in the USA, Canada and Mexico. The two drug firms have just signed an exclusive partnership for the North American area. The Contrave combination treatment targets the central pathways involved in controlling the balance of both food consumption and metabolism, as well as regulating eating behavior, Orexigen informs… (Source: Health News from Medical News Today)

MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising.

Orexigen Partners With Takeda To Commercialize Obesity Drug Contrave (Naltrexone SR/Bupropion SR) is a post from: Prescription Drugs

Clarithromycin attenuates myocardial ischemia–reperfusion injury

admin — Tue, 07 Sep 2010 07:40:07 +0000

Expert Opinion on Therapeutic Targets, Volume 14, Issue 9, Page 881-893, September 2010. (Source: Expert Opinion: Expert Opinion on Therapeutic Targets: Table of Contents)

Clarithromycin attenuates myocardial ischemia–reperfusion injury is a post from: Prescription Drugs