Prescription Drugs 2 Go

Updated Date: Feb 26, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Ventilator-associated pneumonia (VAP) is one of the most common causes of infection in intensive care unit (ICU) patients. Efforts to prevent VAP have focused on both pharmacologic and nonpharmacologic strategies. Two of the more controversial pharmacologic approaches included selective decontamination of the digestive tract (SDD) and decontamination of the oropharynx using topical antimicrobials or antiseptics including Chlorhexidine (CHX). Additionally, avoidance of pharmacotherapy-related risk factors is hypothesized to reduce VAP rates. Successful treatment of VAP is becoming increasingly difficult in the era of antibiotic resistance. Utilization of local antibiograms, implementation of …

(Source: Reactions)

Conclusion. A bundled intervention was successful in preventing horizontal spread of KPC‐producing gram‐negative rods in a long‐term acute care hospital, despite ongoing admission of patients colonized with KPC producers. (Source: Infect Control Hosp Epidemiol Latest Issue)

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

This study evaluated the role of endogenous dentin MMPs in auto-degradation of collagen fibrils within adhesive-bonded interfaces. The null hypotheses tested were that adhesive blends or Chlorhexidine digluconate (CHX) application does not modify dentin MMPs activity and that CHX used as therapeutic primer does not improve the stability of adhesive interfaces over time.Methods: Zymograms of protein extracts from human dentin powder incubated with Adper Scotchbond 1XT (SB1XT) on untreated or 0.2–2% CHX-treated dentin were obtained to assay dentin MMPs activity. Microtensile bond strength and interfacial nanoleakage expression of SB1XT bonded …

Authors: Yanochko GM, Khoh-Reiter S, Evans MG, Jessen BA
Preservatives are used in ocular medications to prevent microbial contamination. The use of Benzalkonium chloride (BAC), the most widely used preservative in ocular medications, has been scrutinized with a number of studies indicating its toxicity to monolayer cultures of corneal epithelial cells. The purpose of this study was to evaluate and compare the toxicity of BAC and other preservatives and common components of ocular formulations on monolayer and stratified air-lifted cultures of Chang conjunctival cells. Air-lifting Chang cells …

Strict adherence to aseptic technique is essential to the prevention of surgical site infection (SSI). One component of aseptic technique is preoperative preparation of the skin before the surgical incision is made. Several skin preparation products approved by the US Food and Drug Administration are used in perioperative settings throughout the United States. These include a 4% Chlorhexidine product, a 2% Chlorhexidine and 70% isopropyl alcohol product, a 70% isopropyl alcohol product, povidone-iodine products, and an iodine povacrylex in isopropyl alcohol product. (Source: AORN Journal)

The aim of the present study was to test the hypothesis that an additional full-mouth disinfection results in a greater clinical and microbiological improvement compared with sole mechanical debridement within one session in patients with peri-implant mucositis and treated chronic periodontitis. The study included 13 partially edentulous patients (mean age 51.5 years) with treated chronic periodontitis and 36 dental implants with mucositis (bleeding on probing and/or a gingival index [ge]1 at least at one site at baseline, absence of peri-implant bone loss during the last 2 years before baseline). After …

When resources are tight, what works best for VAP prevention? American Journal of Critical Care (Source: Medscape Today Headlines)

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