Prescription Drugs 2 Go

Source: eMC (electronic Medicines Compendium)
Area: Other Library Updates > SPC Changes
Change to section 4.8 – Undesirable Effects – Nervous system disorders: Stroke(including haemorrhagic events), Syncope, Transient ischaemic attacks, Migraine. (Source: NeLM – SPC Changes)

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Updated Date: Feb 16, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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To present the methodology, standardization techniques, and results from post hoc test-retest reproducibility analyses for a large, placebo-controlled, multicenter trial, employing urodynamic studies (UDS) to assess the impact of daily tadalafil on men with lower urinary tract symptoms (LUTS) with or without benign prostatic obstruction (BPO).UDS implemented International Continence Society (ICS) Good Urodynamic Practice guidelines and standardized urodynamic and LUTS terminology. Further standardization procedures included: equipment calibration; a detailed procedure manual and centralized training; and implementation of a central reader. Measures included: monitoring of invalid studies, comparison of actual versus …

Purpose: We explored the impact of once daily tadalafil on urodynamic measures in men with lower urinary tract symptoms secondary to clinical benign prostatic hyperplasia via invasive and noninvasive urodynamic studies.Materials and Methods: We conducted a multicenter, randomized, double blind, placebo controlled clinical trial comparing once daily tadalafil 20 mg vs placebo during 12 weeks in men with lower urinary tract symptoms secondary to clinical benign prostatic hyperplasia with or without bladder outlet obstruction. Invasive and noninvasive urodynamics, International Prostate Symptom Score and general safety were assessed. The primary study …

Human orcas performing for pretzels. Chickens scared to death of Denny’s Grand Slam offers. That Dorito’s kids who doesn’t want to share his mom, or his Dorito’s–and not necessarily in that order–with mom’s new suitor.Yes, the Superbowl is the one time of the year we aren’t grumbling about advertising as interruption, but looking to it for entertainment. And the advertising industry knows it, unveiling their riskiest, most expensive, and sometimes (they hope) funniest or most moving efforts for the occasion. Sometimes the ads are too hokey or even incomprehensible for …

Health News of the Day is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day:
Vitamin nation – “Mediterranean diet does not come in a pill or potion. You have to eat the foods to reap the rewards” http://bit.ly/77P7TO
Diagnosis and management of vitamin D deficiency – BMJ review, 2010 http://bit.ly/6yYT6d
New ED drug avanafil is effective in just 15 minutes, far faster than …

We describe a patient who developed unilateral sudden sensorineural hearing loss possibly related to the use of vardenafil for erectile dysfunction. To our knowledge, only one other case of hearing loss related to this drug class has been published. Our patient was a 57-year-old man who came to the emergency department with right-sided mild-to-moderate hearing loss in the 500-3000-Hz range, confirmed by audiogram, that occurred after ingestion of vardenafil. The patient was hospitalized 2 days later for administration of intravenous dexamethasone, followed by oral prednisone. He reported that his hearing …

Administration of the phosphodiesterase type 5 inhibitor tadalafil citrate is associated with a reduction in oxidative stress and increased serum levels of paraoxonase-1, Turkish researchers have shown. (Source: MedWire News – Lipidology)

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The FDA announced this week that Atlas Operations has initiated a recall of their dietary supplements marketed for “male enhancement”. Analysis revealed that some of the products contained sulfoaildenafil, a sildenafil analogue.  This drug has the potential to cause dangerous decreases in blood pressure, especially for patients taking certain other medications such as nitroglycerin.  According to a press release from the company, some of the products recalled include Staminil, Love Fuel, Erexxx, Finally on Demand, and Whatzup.  The take-home lesson for clinicians is that in addition to asking that middle-aged …

This article discusses the available knowledge regarding several disorders associated with pulmonary hypertension in children: idiopathic pulmonary arterial hypertension (IPAH), pulmonary capillary hemangiomatosis, pulmonary veno-occlusive disease, hemoglobinopathies, hepatopulmonary syndrome, portopulmonary hypertension and HIV. Three classes of drugs have been extensively studied for the treatment of IPAH in adults: prostanoids (epoprostenol, treprostinil, iloprost, beraprost), endothelin receptor antagonists (bosentan, sitaxsentan, ambrisentan), and phosphodiesterase inhibitors (sildenafil, tadalafil). These medications have been used in treatment of children with pulmonary arterial hypertension, although randomized clinical trial data is lacking. As pulmonary vasodilator therapy in cer…