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[2 Mar 2010 | No Comment | 4 views]

Conclusions  The synergistic combination of fosfomycin with other antibiotics may be a useful alternative treatment option for Gram-negative
and Gram-positive infections. Additional studies using more stringent definitions of synergy, and studies reporting on the
clinical efficacy of fosfomycin combinations in the current era of high antimicrobial resistance are needed.
Content Type Journal ArticleCategory PharmacodynamicsDOI 10.1007/s00228-010-0794-5Authors
Antonia C. Kastoris, Alfa Institute of Biomedical Sciences (AIBS) Athens GreecePetros I. Rafailidis, Alfa Institute of Biomedical Sciences (AIBS) Athens GreeceEvridiki K. Vouloumanou, Alfa Institute of Biomedical Sciences (AIBS) Athens GreeceIoannis D. Gkegkes, Alfa Institute of Biomedical Sciences …

Ciprofloxacin »

[2 Mar 2010 | No Comment | 4 views]

Authors: Sahin I, Barut HS
Peritonitis is a major cause of morbidity in continuous ambulatory peritoneal dialysis (CAPD). Aeromonas hydrophila is a rare cause of peritonitis in patients on CAPD. We herewith report a 44-year-old female patient on CAPD with Aeromonas hydrophila peritonitis. Peritoneal fluid grew Aeromonas hydrophila. The patient reported that she had accidentally dropped her peritoneal dialysis catheter into the toilet. Susceptibility testing revealed that it is susceptible to ceftazidime, but resistant to Ciprofloxacin. The patient was treated successfully with intravenous ceftazidime for 2 days …

Ciprofloxacin »

[2 Mar 2010 | No Comment | 6 views]

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Ciprofloxacin »

[26 Feb 2010 | No Comment | 1 views]

A series of novel 7-(3-alkoxyimino-4-methyl-4-methylaminopiperidin-1-yl)fluoroquinolone derivatives were designed, synthesized, and characterized by 1H-NMR, MS, and HRMS. These fluoroquinolones were evaluated for their in-vitro antibacterial activity against representative Gram-positive and Gram-negative strains. Generally, all of the target compounds have considerable antibacterial activity against the tested forty strains, and exhibit exceptional potency in inhibiting the growth of methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) ATCC33591 (MICs: 0.06 to 2 [mu]g/mL). In particular, compounds 14, 19, 28, and 29 are fourfold more potent than Ciprofloxacin against MSSA 08-49. Compounds 23, 26, …

Ciprofloxacin »

[26 Feb 2010 | No Comment | 2 views]

Persisters are specialized survivor cells that arise in populations of E. coli after antibiotic-mediated DNA damage induces the production of a small membrane-acting peptide TisB, which causes reversible dormancy. The TisB-dependent persisters are tolerant to multiple antibiotics. (Source: PLoS Biology: Archived Table of Contents)

Ciprofloxacin »

[26 Feb 2010 | No Comment | 2 views]

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Ciprofloxacin »

[26 Feb 2010 | No Comment | 2 views]

Aradigm Corporation (OTCBB:ARDM) (the “Company”) announced that it dosed the first patient in the U.S… (Source: Asthma / Respiratory News From Medical News Today)

Ciprofloxacin »

[26 Feb 2010 | No Comment | 2 views]

Aradigm Corporation (OTCBB:ARDM) (the “Company”) announced that it dosed the first patient in the U.S. as part of its ORBIT-1 (Once-daily Respiratory Bronchiectasis Inhalation Treatment) trial, an international, randomized, double-blind, placebo-controlled Phase 2b study designed to evaluate the Company’s inhaled liposomal Ciprofloxacin (ARD-3100) in patients with non-cystic fibrosis bronchiectasis (BE) under a U.S. IND. This orphan disease indication is a chronic, severe respiratory disease and there are currently no approved treatments for this disease in the U.S… (Source: Health News from Medical News Today)

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Ciprofloxacin »

[26 Feb 2010 | No Comment | 2 views]

In conclusion, JNJ-Q2 exhibits a range of antibacterial activity in vitro that is supportive of its further evaluation as a potential new agent for the treatment of skin and respiratory tract infections.
PMID: 20176911 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Ciprofloxacin »

[26 Feb 2010 | No Comment | 2 views]

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