Prescription Drugs 2 Go

We present a case of systemic Mycobacterium chelonae infection in an immunosuppressed patient with systemic lupus erythematosus (SLE), idiopathic hypoparathyroidism, and hypothyroidism.
The patient was treated for 3 months for skin infection with clarithromycin monotherapy. Since her condition deteriorated,
the antibiotic therapy was switched to intravenously administered Clindamycin, cloxacillin, and meropenem. Due to further
deterioration and isolation of M. chelonae from the blood culture, antimicrobial therapy was changed to azithromycin and amikacin. Drug-test sensitivity was performed,
and the isolate was susceptible to clarithromycin only. The patient’s deteriorating status prevented orally …

Intravitreal injection of Clindamycin and dexamethasone for active ocular toxoplasmosis may be safer and more convenient than standard treatment, according to researchers in Iran. Reuters Health Information (Source: Medscape Pharmacist Headlines)

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Authors: Joo HS, Chan JL, Cheung GY, Otto M
Tetracycline, Clindamycin, and other protein synthesis inhibitors at subinhibitory concentrations significantly increased expression of the pivotal virulence regulator agr and production of the agr-regulated cytolytic phenol-soluble modulins in the community-associated MRSA strain USA300. Our results suggest that such protein synthesis inhibitors may exacerbate progression of CA-MRSA disease when applied at concentrations that are too low or when treating infections caused by strains resistant to those antibiotics.
PMID: 20713669 [PubMed - as supplied by publisher] (Source: …

Updated Date: Aug 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Conclusions: Fifty percent of Staphylococcal spp. were ER among which 23.48% were iMLS B phenotypes. Eighty-seven per cent of iMLS B phenotypes were observed to be methicillin-resistant. The high frequency of methicillin resistance isolates (87.12%) with in vitro inducible Clindamycin resistance at our institute raises concern of Clindamycin treatment failures with methicillin-resistant infections. So we recommend that microbiology laboratories should include the D-test for inducible resistance to Clindamycin in the routine antibiotic susceptibility testing. (Source: Journal of Postgraduate Medicine)

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Abstract  The prevalence of antibiotic resistance and their genetic determinants in colonizing group B streptococci (GBS) sampled in
a Swedish nationwide survey was examined. In five GBS isolates (1.3%), kanamycin/amikacin resistance and the presence of the
aphA-3 gene was identified. Three of these isolates carried the aad-6 gene and were streptomycin-resistant. Screening with kanamycin and streptomycin 1,000-μg disks enabled a rapid and easy detection
of these isolates. In all, 312/396 (79%) GBS were tetracycline-resistant and 95% of the examined isolates harbored the tetM gene. Among the 22 (5.5%) GBS resistant to …

Updated Date: Aug 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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This study emphasizes that effects of rRNA mutations at the PTC are organism-dependent. Moreover, the data show a non-predictable cross-resistance pattern between linezolid, chloramphenicol, Clindamycin, and valnemulin. The data underscore the significance of mutations at distal nucleotides, either alone or in combination with other mutated nucleotides, in contributing to linezolid resistance.
PMID: 20696869 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Authors: Coyne S, Rosenfeld N, Lambert T, Courvalin P, Périchon B
Acinetobacter baumannii is a major nosocomial pathogen which frequently develops multidrug resistance by acquisition of antibiotic resistance genes and overexpression of intrinsic efflux systems, such as the RND efflux pumps AdeABC and AdeIJK. A third RND system was characterized by studying spontaneous mutants BM4663 and BM4664, that were selected in presence of chloramphenicol and norfloxacin, respectively, from the AdeABC, AdeIJK defective derivative A. baumannii BM4652. They exhibited enhanced resistance to fluoroquinolones, tetracycline-tigecycline, chloramphenicol, Clindamycin, trimethoprim, sulfamethoxazol, …

Updated Date: Aug 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))