Prescription Drugs 2 Go

CONCLUSION: CA-MRSA pneumonia is also not necessarily a post influenza infection. Despite necrotizing features in many, the mortality of CA-MRSA pneumonia in our series is lower than previously reported and patients do not routinely require ICU care. Treatment with antibiotics which inhibit exotoxin production and/or nontoxigenic strains may explain this improved outcome.
PMID: 20173050 [PubMed - as supplied by publisher] (Source: Chest)

Authors: Muller AE, Mouton JW, Oostvogel PM, Dörr PJ, Voskuyl RA, Dejongh J, Steegers EA, Danhof M
The study was performed to describe the pharmacokinetics of intravenously administered Clindamycin in pregnant women. 7 pregnant women treated with Clindamycin were recruited. Maternal blood, arterial and venous umbilical cord blood samples were obtained. Maternal Clindamycin concentrations were analyzed with nonlinear mixed-effects modeling using NONMEM. Data were best described by a linear three-compartment model. Clearance and volume of distribution at steady state were 10.0 L/h and 6.32 x 10(3) L. …

Authors: Woosley LN, Castanheira M, Jones RN
In vitro activity of CEM-101, a new fluoroketolide, was determined against Gram-positive organisms with various macrolide susceptibility profiles. Experiments for determination of MIC and MBC, timed-killing, single-step and multistep mutation rates, erythromycin induction of resistance, post-antibiotic effect (PAE) and drug interactions were performed for CEM-101 and results compared to telithromycin, macrolides and lincosamides. CEM-101 MBC results remained overall lower than those of telithromycin and CEM-101 displayed a two-fold greater potency compared the ketolide. Timed-killing curve testing resulted in CEM-101 having …

In this issue of The Journal, Blaschke et al from Salt Lake City, Utah, provide the case that was bound to happen. With increasing resistance of group B Streptococcus (GBS) to erythromycin and Clindamycin, and too-quick, too-easy reflex to substitute Clindamycin for penicillin or ampicillin when mother has a history of penicillin “allergy,” the math was going to add up to transmission and disease due to a Clindamycin-resistant GBS in a newborn. Blaschke et al provide the case—an “old fashioned” one—of severe early-onset disease in an otherwise healthy term infant, …

[Ann Emerg Med. 2010;55:302.] A 53-year-old man presented with a painful skin lesion on his left lower leg, without trauma. The lesion was initially pruritic and had appeared spontaneously 2 weeks earlier. The patient had been evaluated 1 week earlier and was prescribed Clindamycin for presumed cellulitis. Despite this, the lesion continued to grow. The patient had a history of peripheral vascular disease and had resumed receiving warfarin sodium for this 1 week before appearance of the lesion. On physical examination, the patient was afebrile, with a 5-cm-×-7-cm nonraised …

Authors: Boente RF, Ferreira LQ, Falcão LS, Miranda KR, Guimarães PL, Santos-Filho J, Vieira JM, Barroso DE, Emond JP, Ferreira EO, Paula GR, Domingues RM
Susceptibility to five antimicrobials was determined for Bacteroides spp. (n= 52) and Parabacteroides distasonis (n= 8). All isolates were susceptible to metronidazole. The resistance rates to ampicillin, cefoxitin, tetracycline and Clindamycin were 98%, 9.6%, 65.3% and 19.2% of the Bacteroides strains, respectively. The genes cepA, cfiA, cfxA, tetQ, ermF and nim were found in 69.2%, 17.3% 9.6%, 50%, 7.7% and 3.8% for …

Updated Date: Feb 16, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clin Microbiol Infect Knowledge of the epidemiology of Streptococcus agalactiae in Portugal is limited: therefore, the present study aimed to investigate the carriage rate of S. agalactiae among Portuguese women of reproductive age and the prevalence of antibiotic resistance, as well as to perform a molecular characterization of the clinical isolates. S. agalactiae was recovered from 6.2% of 4269 women during the period 2005[ndash]2007, with a predominance of capsular genotypes III (35%), V (33%), Ia (16%) and II (10%) in a sample of 100 isolates. To our knowledge, this is …

Updated Date: Feb 18, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Updated Date: Feb 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))