Prescription Drugs 2 Go

Source: BMJ
Area: News
The British Medical Journal has featured a review on the diagnosis and management of lichen sclerosis. The review starts with a case vignette, and discusses clinical features and investigations required for the diagnosis.
 
In terms of management, the review states, “After diagnosis, the accepted treatment is with the very potent topical steroid Clobetasol propionate ointment. No controlled trials have been published to establish the best regime, but the guidelines suggest a single application at night for four weeks followed by alternate nights for four weeks and …

Conclusions Hypothalamus[ndash]pituitary[ndash]adrenal inhibition is substantial during initial treatment with aqueous CP three times daily. (Source: Journal of the European Academy of Dermatology and Venereology)

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Updated Date: Jan 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Updated Date: Jan 27, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Please cite this paper as: Topical hydrocortisone, Clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice. Experimental Dermatology 2010.Abstract: Topical corticosteroids such as hydrocortisone-17-butyrate (HCB) and Clobetasol-17-propionate (CP) and vitamin D3 derivatives such as calcipotriol (CAL) are widely used to treat psoriasis. The immunosuppressive effects of corticosteroids make their topical use a concern for skin carcinogenicity. Few studies have assessed the effect of topical corticosteroids and topical vitamin D3 derivatives on photocarcinogenesis induced by ultraviolet radiation. We investigated whether HCB, CP, or CAL …

Updated Date: Jan 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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We report the cases of two women who developed erythematous skin plaques with pustules that coalesced and evolved into erosions and crusted areas. Histology showed epidermal spongiosis with subcorneal pustules and a dermal infiltrate with eosinophils and neutrophils. Lesions were treated with topical Clobetasol propionate 0.05% for 10 days followed by topical tacrolimus daily until complete resolution, and then twice weekly for 1 year, without relapse. The response to topical corticosteroids and tacrolimus further support the close relationship with erosive pustular dermatosis of the scalp. Topical therapy with tacrolimus may …

We report a 62-year-old female patient presenting with an 18-month history of pruritus and burning of the vulva. Clinical examination of the vulva showed a tender nodule of the right labium minus. Histology confirmed Langerhans cell histiocytosis. Systemic involvement was excluded. Within 1 month the use of Clobetasol propionate ointment led to resolution of both the patient’s symptoms and the clinical appearance of the affected right labium minus. This resolution was maintained 12 months later. (Source: Australasian Journal of Dermatology)

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Perrigo Company (Nasdaq: PRGO
; TASE) today announced that it has filed an Abbreviated New Drug Application for Clobetasol Propionate Topical Spray, 0.05%, a generic form of Clobex® Spray. (Source: Pharmaceutical Online News)

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We report a case of severe psoriatic nail dystrophy involving all 20 nails successfully treated by low dose MTX. A previously healthy 11-year-old girl presented with painful deformity involving all 20 nails that developed over a one-month period. Examination revealed geographic and fissured tongue, as well as severe nail dystrophy of all 20 nails characterized by erythematous swelling of the nail folds, yellowish discoloration of nail plates with pitting, severe crumbling and destruction, transverse depressions, prominent oil spots, and swelling of proximal nail. Topical Clobetasol propionate and calcipotriol were tried …